Integrated Canine Data Commons

Understanding the biological relationship between human and canine cancers.


The Integrated Canine Data Commons (ICDC) was established to further research on human cancers by enabling comparative analysis with canine cancer. Canines have many genes similar to human genes, which are involved in cancers in similar ways. They develop spontaneous diseases and respond to treatments like humans, live in a family environment shared with humans, and like humans receive health care and participate in clinical trials. Canines are also of scientific interest because of their accelerated aging process.

The data in the ICDC are structured and queryable according to the ICDC data model. Submitted data are harmonized to maintain data and metadata consistency, integrity and availability to the ICDC users and the rest of the CRDC.

All data in the ICDC are open-access and, with appropriate attribution, can be included in publications. In addition to the ICDC’s graphical user interface, there is also an Application Programming Interface (API) that software programs may use to query the data.

The data files of the ICDC are available for analysis in the CRDC Cloud Resources. ICDC users can build cohorts of interest in the ICDC and then analyze the associated data files in the Seven Bridges Cancer Genomics Cloud (SB-CGC).

Data Types

The ICDC contains multiple data types.

Experimental Strategy Data Type File Format
Clinical and Biospecimen Clinical and Biospecimen Metadata JSON
RNA-seq Transcriptomics BAM, TXT
Whole Genome Sequencing Genomics BAM, VCF
Whole Exome Sequencing Genomics BAM, VCF
Genotyping Array Genomics TXT
DNA Methylation Analysis Genomics BAM



Study Code Study Type Study Name
COTC007B Clinical Trial Preclinical Comparison of Three Indenoisoquinoline Candidates in Tumor-Bearing Dogs
COTC022 Clinical Trial A Contemporaneous Controlled Study of the Standard of Care (SOC) in Dogs with Appendicular Osteosarcoma
GLIOMA01 Genomics Comparative Molecular Life History of Spontaneous Canine and Human Gliomas
MGT01 Genomics Molecular Homology and Differences Between Spontaneous Canine Mammary Cancer and Human Breast Cancer
NCATS-COP01 Transcriptomics Models for Diagnosis and Treatment of Human Cancers Using Comparative Canine-Human Transcriptomics
ORGANOIDS01 Genomics Characterization of Healthy and Urothelial Carcinoma Canine Organoids for Applications in Personalized Medicine and Translational Research
OSA01 Genomics A Multi-Platform Sequencing Analysis of Canine Appendicular Osteosarcoma
TCL01 Genomics Whole exome sequencing analysis of canine cancer cell lines
UBC01 Clinical Trial Antitumor Activity and Molecular Effects of Vemurafenib in Dogs with BRAF-mutant Bladder Cancer
UBC02 Genomics Basal and Luminal Molecular Subtypes in Naturally-Occurring Canine Urothelial Carcinoma Are Associated With Tumor Immune Signatures and Dog Breed
UC01 Genomics Whole Exome Sequencing Analysis of Canine Urothelial Carcinomas without BRAF V595E

Anatomical Sites

The ICDC contains data from multiple programs/projects/studies. The ICDC currently has data with multiple sites including:

  • Bladder
  • Bone
  • Femur
  • Humerus
  • Mandible
  • Radius
  • Tibia
  • Bone Marrow
  • Brain
  • Kidney
  • Lung
  • Lymph Nodes
  • Skin
Explore the Integrated Canine Data Commons