Repository

Integrated Canine Data Commons

(ICDC)
Understanding the biological relationship between human and canine cancers.
ICDC

Overview

The Integrated Canine Data Commons (ICDC) was established to further research on human cancers by enabling comparative analysis with canine cancer. Canines have many genes similar to human genes, which are involved in cancers in similar ways. They develop spontaneous diseases and respond to treatments like humans, live in a family environment shared with humans, and like humans receive health care and participate in clinical trials. Canines are also of scientific interest because of their accelerated aging process.

The data in the ICDC are structured and queryable according to the ICDC data model. Submitted data are harmonized to maintain data and metadata consistency, integrity and availability to the ICDC users and the rest of the CRDC.

All data in the ICDC are open-access and, with appropriate attribution, can be included in publications. In addition to the ICDC’s graphical user interface, there is also an Application Programming Interface (API) that software programs may use to query the data.

The data files of the ICDC are available for analysis in the CRDC Cloud Resources. ICDC users can build cohorts of interest in the ICDC and then analyze the associated data files in the Seven Bridges Cancer Genomics Cloud (SB-CGC).

Data Types

The ICDC contains multiple data types.

Experimental StrategyData TypeFile Format
Clinical and BiospecimenClinical and Biospecimen MetadataJSON
RNA-seqTranscriptomicsBAM, TXT
Whole Genome SequencingGenomicsBAM, VCF
Whole Exome SequencingGenomicsBAM, VCF
Genotyping ArrayGenomicsTXT
DNA Methylation AnalysisGenomicsBAM

 

Datasets

Study CodeStudy TypeStudy Name
COTC007BClinical TrialPreclinical Comparison of Three Indenoisoquinoline Candidates in Tumor-Bearing Dogs
COTC022Clinical TrialA Contemporaneous Controlled Study of the Standard of Care (SOC) in Dogs with Appendicular Osteosarcoma
GLIOMA01GenomicsComparative Molecular Life History of Spontaneous Canine and Human Gliomas
MGT01GenomicsMolecular Homology and Differences Between Spontaneous Canine Mammary Cancer and Human Breast Cancer
NCATS-COP01TranscriptomicsModels for Diagnosis and Treatment of Human Cancers Using Comparative Canine-Human Transcriptomics
ORGANOIDS01GenomicsCharacterization of Healthy and Urothelial Carcinoma Canine Organoids for Applications in Personalized Medicine and Translational Research
OSA01GenomicsA Multi-Platform Sequencing Analysis of Canine Appendicular Osteosarcoma
OSA03GenomicsComparative Analysis Using Whole Genome Bisulfite Sequencing of Human and Canine Osteosarcoma
TCL01GenomicsWhole Exome Sequencing Analysis of Canine Cancer Cell Lines
UBC01Clinical TrialAntitumor Activity and Molecular Effects of Vemurafenib in Dogs with BRAF-mutant Bladder Cancer
UBC02GenomicsBasal and Luminal Molecular Subtypes in Naturally-Occurring Canine Urothelial Carcinoma Are Associated With Tumor Immune Signatures and Dog Breed
UC01GenomicsWhole Exome Sequencing Analysis of Canine Urothelial Carcinomas without BRAF V595E
OSA03GenomicsComparative Analysis Using Whole Genome Bisulfite Sequencing of Human and Canine Osteosarcoma

Anatomical Sites

The ICDC contains data from multiple programs/projects/studies. The ICDC currently has data with multiple sites including:

  • Bladder
  • Bone
  • Femur
  • Humerus
  • Mandible
  • Radius
  • Tibia
  • Bone Marrow
  • Brain
  • Kidney
  • Lung
  • Lymph Nodes
  • Skin
Image
Canine
Explore the Integrated Canine Data Commons