Repository

Integrated Canine Data Commons

(ICDC)
Understanding the biological relationship between human and canine cancers.
ICDC

Overview

The Integrated Canine Data Commons (ICDC) was established to further research on human cancers by enabling comparative analysis with canine cancer. Canines have many genes similar to human genes, which are involved in cancers in similar ways. They develop spontaneous diseases and respond to treatments like humans, live in a family environment shared with humans, and like humans receive health care and participate in clinical trials. Canines are also of scientific interest because of their accelerated aging process.

The data in the ICDC are structured and queryable according to the ICDC data model. Submitted data are harmonized to maintain data and metadata consistency, integrity and availability to the ICDC users and the rest of the CRDC.

All data in the ICDC are open-access and, with appropriate attribution, can be included in publications. In addition to the ICDC’s graphical user interface, there is also an Application Programming Interface (API) that software programs may use to query the data.

The data files of the ICDC are available for analysis in the CRDC Cloud Resources. ICDC users can build cohorts of interest in the ICDC and then analyze the associated data files in the Seven Bridges Cancer Genomics Cloud (SB-CGC).

 

Data Types

The ICDC contains multiple data types.

Experimental Strategy Data Type File Format
Clinical and Biospecimen Clinical and Biospecimen Metadata JSON
RNA-seq RNA-seq BAM, TXT
Whole Genome Sequencing Whole Genome Sequencing BAM, VCF
Whole Exome Sequencing Whole Exome Sequencing BAM, VCF
Genotyping Array Genotyping Array TXT

 

Datasets

  • COTC007B – Clinical trial
  • GLIOMA01 – Genomic sequencing, Clinical data, Imaging available through TCIA
  • NCATS-COP-01 – Genomic sequencing
  • Vemurafenib Bladder Cancer – Clinical trial with RNAseq, Imaging, Immunology and pharmacokinetic data

Anatomical Sites

The ICDC contains data from multiple programs/projects/studies. The ICDC currently has data with multiple sites including:

  • Bladder
  • Femur
  • Humerus
  • Mandible
  • Radius
  • Tibia
  • Brain
  • Lung
  • Lymph Nodes
Image
Canine
Explore the Integrated Canine Data Commons