The NCI CRDC provides access to a variety of open, registered, and controlled datasets from NCI programs and key external cancer programs. Many of these datasets are accessible through the CRDC Cloud Resources (CRs), where users can also bring their own data to a secure cloud workspace for comparative analysis.
| Dataset Name | Description | Accessible Through* |
|---|---|---|
| Applied Proteogenomics Organizational Learning and Outcomes (APOLLO) | A collaboration between NCI, the Department of Defense (DoD), and the Department of Veterans Affairs (VA), that incorporates proteogenomic data with patient care, with a focus on the activity and expression of the proteins that the genome encodes | GDC, PDC, SB |
| Cancer Genome Characterization Initiatives (CGCI) | An initiative examining genomes, exomes, and transcriptomes of various types of adult and pediatric cancers | GDC, SB, ISB |
| Children's Brain Tumor Tissue Consortium (CBTTC) | A collaborative research consortia focused on identifying therapies for children with brain tumors | PDC, SB, ISB |
| Childhood Cancer Data Initiative (CCDI) | A consortium of children’s hospitals, clinics, or networks that make their clinical care and research data accessible | CDS, SB |
| Clinical Proteomic Tumor Analysis Consortium (CPTAC) | A national effort to accelerate the understanding of the molecular basis of cancer through the application of proteogenomics (large-scale proteome and genome analysis) | GDC, PDC, FC, ISB, SB, IDC |
| Comparative molecular life history of spontaneous canine and human gliomas (GLIOMA01) | A collaborative effort to characterize the genomic and transcriptomic landscape of canine glioma to enable cross-species comparative genomic analysis of sporadic glioma | ICDC, SB |
| Foundation Medicine (FM) | Foundation Medicine Inc., a molecular information company, makes accessible sequencing data from thousands of adult patients, in an effort to match patients with personalized treatment plans | GDC, SB, ISB |
| Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) | A research collaboration to detect colorectal cancer susceptibility loci using genome-wide sequencing | CDS, SB |
| Human Cancer Model Initiative (HCMI) | An international consortium that is generating novel, next-generation, and tumor-derived culture models complete with genomic and clinical data | GDC, SB, ISB |
| Human Tumor Atlas Network (HTAN) | An NIH initiative that makes accessible three-dimensional atlases of the cellular, morphological, and molecular features of human cancers over time, based on a diverse cancer patient populations, including minority and underserved patients, as well as individuals with high-risk hereditary tumors | CDS, IDC, SB |
| International Cancer Proteogenomic Consortium (ICPC) | An international consortium that brings together more than a dozen countries to study the application of proteogenomic analysis in predicting cancer treatment success, and to share data and results with researchers worldwide | PDC, SB, ISB |
| Multiple Myeloma Research Foundation (MMRF) | The Foundation shares secure, molecular and clinical data, including longitudinal information collected over the course of disease for many patients | GDC, SB, ISB |
| The Cancer Genome Atlas (TCGA) | A collaboration between NCI and the National Human Genome Research Institute (NHGRI) that has characterized tumor and normal tissues from thousands of patients and dozens of cancer types | GDC, FC, SB, ISB, IDC |
| Therapeutically Applicable Research to Generate Effective Treatments (TARGET) | A consortium of extramural and NCI investigators working to characterize and understand hard-to-treat childhood cancers and translate findings into the clinic | GDC, FC, SB, ISB |
*Abbreviations:
Data Commons: GDC: Genomic Data Commons; PDC: Proteomics Data Commons; IDC: Imaging Data Commons; ICDC: Integrated Canine Data Commons; CDS: Cancer Data Service
Cloud Resources: FC: FireCloud/Broad Institute; SB: Seven Bridges/Cancer Genomic Cloud from Velsera; ISB: Institute for Systems Biology/Cancer Gateway in the Cloud